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found that constitutive IFN- signaling induced by depletion of the tumor suppressor transcription factor Elf5, together with its ubiquitin ligase FBXW7, increases the number of highly immunosuppressive neutrophils in the TME, which in turn promotes tumor growth and metastasis, leading to a worse prognosis of TNBC (144)

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Maddalena G, der Pol YV, Villarreal OE, Coker O, Lee HM, Rivers Z, Covert W, Diao S, Lonardi S, Rogers JE, Dasari A, Guinney J, Kopetz S , Raghav K

Neurotox Res 28:361371